The Prevalence of Extended Spectrum Beta-Lactamase Producing Uropathogenic Escherichia coli from Mouau Female Hostel Students

Aim: The study is aimed at determining the antimicrobial susceptibility pattern and production of Extended-spectrum Βeta-Lactamase (ESBLs) among Escherichia coli isolates from urine samples.
 Methods: A total 35 samples early morning mid-stream about 10-15 ml were collected Michael Okpara University Agriculture Umudike (MOUAU) female hostel students; using sterile plastic containers. Each sample was inoculated on MacConkey Agar (MCA). Isolates identified based morphological features, Gram staining, biochemical characterization. antibiotic test done by Kirby Bauer Disc diffusion method Muller Hinton agar. ESBL detection as per Clinical Laboratory Standard Institute (CLSI) guidelines, double disc synergy method.
 Results: reviewed a 12 which (34.29%) obtained samples. results showed that most susceptible to Ofloxacin with 83.3% susceptibility, followed Levofloxacin (66.7%), whereas gentamicin, nalidixic acid, cefuroxime, cefotaxime exhibited rate 33.3%. On other hand, highest resistance imipenem (96.7%), Amoxicillin ampiclox 83.3%, while least percentage observed in (8.3%) (16.7%). E. detected 25.0% potential producers. result multiple index isolate (E20) significantly higher than p<0.05, E3, E7, E10 E12 had same pattern.
 Conclusion: So drug due severe threat UTIs, narrowing down choice antibiotics for treatment. So, there need introduce routine screening all uropathogenic coli, causing urinary tract infections.